Larry Lands

Position
Director, Pediatric Respiratory Medicine, Montreal Children’s Hospital
Professor, Department of Pediatrics, McGill University
Associate Member, McGill School of Dietetics & Human Nutrition, McGill University

Research Theme

Inhaled RNA and small molecule therapeutics, modulation of innate immunity, exercise limitation, pulmonary physiology.

Keywords

Cystic fibrosis (CF), primary ciliary dyskinesia (PCD), severe asthma, lipid nanoparticles, mucus rheology, immune modulation, exercise, oscillometry, translational research

Research Interests

Our translational research lab is focused on developing therapeutics in Cystic Fibrosis, Primary Ciliary Dyskinesia, severe asthma, and COPD. We are developing inhaled RNA and small molecule therapeutics using lipid nanoparticles. We are also working to understand how to prevent lung inflammation caused by Interleukin-17. Other work examines how we can rejuvenate basal cells to repair damaged lung epithelium. We utilize primary respiratory epithelial cells from nasal and airway brushings and lung biopsies and have established a Primary Ciliary Dyskinesia epithelial cell bank. Clinical research is oriented to understanding exercise limitation in chronic lung diseases, obesity, and cancer. We are also developing a non-invasive technique called oscillometry to detect early lung disease in Cystic Fibrosis and infants living with chronic lung disease.

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