2024-2025 RESP Journal Club RESP JOURNAL CLUB with RECRU and Meakins members. This journal club is open to all clinical and research faculty, trainees, fellows, and residents. The goal of this journal club is to critically evaluate a research article (or topic) from both clinical and fundamental science perspectives. Publications will be jointly chosen by RECRU and Meakins faculty members, who will facilitate discussion of the article. The publications will cover the various research themes of the RESP program, with a focus on translational research. Presentations will be delivered by faculty and/or trainees/fellows and all discussions will be moderated. Articles will be distributed 1 week in advance of the Journal Club date. Frequency: Monthly on Fridays at 12 noon via ZOOM
2024-2025 RESP Journal Club
Checklist and questions for presenters to integrate into their presentation and to use for moderating the discussion:
ACTS INTERPRETATIONS What is the stated rationale/motivation for this study? Is this an important clinical/scientific problem? What is the stated hypothesis (or objective)? Does the hypothesis (or objective) address the stated rationale)? What are the stated methods used to test the hypothesis (achieve the objective)? Will the methods test the stated hypothesis? What are the results? Are the results presented appropriately? What is the authors’ interpretation of the results? Do you agree with their interpretation? What are the stated limitations of the study? Do you agree with the stated limitations? Does this study provide the definitive answer the original problem?
2023-2024 RESP Journal Club
DATE RECRU MODERATOR MEAKINS MODERATOR TOPIC & ARTICLE December 8, 2023 Sushmita Pamidi / Diana Escobar Olaya POSTPONED TBC Article 1: January 12, 2024 John Kimoff / Romeo Alam —– Article 1: Adaptive servo-ventilation for sleep-disordered breathing in patients with heart failure with reduced ejection fraction (ADVENT-HF): a multicentre, multinational, parallel-group, open-label, phase 3 randomised controlled trial. February 2, 2024 Kevin Schwartzman /TBC Article 1: Treatment Strategy for Rifampin-Susceptible Tuberculosis March 15, 2024 Jonathan Campbell / Bader Alkharisi TBC Article 1: Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial May 3, 202411 am-noon Benjamin Mappin-Kasirer / Bryan Ross Elizabeth Fixman Article 1: Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2): a non-inferiority, multicentre, double-blind, placebo-controlled, randomised controlled trial Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice June 7, 2024 Benjamin Smith / Amanda Marino Darcy Wagner Article 1: Autologous transplantation of P63+ lung progenitor cells for chronic obstructive pulmonary disease therapy
2023-2024 RECRU Seminars
RECRU seminars: Fridays at 1pm
DATE PRESENTER TITLE October 13, 2023 Benjamin Smith Understanding the intersection of inflammation and lung function trajectories across diverse populations to maximize lifelong health October 20, 2023 Deborah Assayag CIHR Lung Health Team grant – a personalized approach to autoimmune related ILD November 24, 2023 Jean Bourbeau & Sushmita Pamidi Clinical trial unit and training at the RI-MUHC: ACT/CANTRAIN December 15 Faiz Ahmad KhanPOSTPONED February 9, 2024 Nicole Ezer CIHR project: Eosnionphilia and post operative readmission after lung cancer resection March 22, 2024 Tania Janaudis-Ferreira Emerging results from an RCT of virtual rehabilitation for individuals with Long COVID April 12, 2024 Kevin Schwartzman Modeling to Inform TB Elimination April 26, 2024 Jonathon Campbell Estimating the Return on Investment of Scaling Tuberculosis Screening and Preventive Treatment in Brazil, Georgia, Kenya, and South Africa May 24, 2024 Nermin Diab POSTPONED June 14, 2024AT NOON Nermin Diab Understanding the links between insulin resistance and obesity in asthma outcomes and airway hyperresponsiveness June 21, 2024AT NOON Bryan Ross FRQS Junior 1 competition: A research program in COPD
2022-2023 RESP Journal Club
DATE RECRU MODERATOR MEAKINS MODERATOR TOPIC & ARTICLE October 21, 2022 Deborah Assayag Jun Ding Article 1: The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics November 18, 2022 Benjamin Smith Jun Ding Article1: Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease January 13, 2023 Faiz Ahmed Khan POSTPONED February 3, 2023 Sushmita Pamidi Basil Petrof Article 1: Inflammasome Activation: A Keystone of Proinflammatory Response in Obstructive Sleep Apnea Positive Airway Pressure Adherence, Mortality and Cardiovascular Events in Patients with Sleep Apnea March 10, 2023 Kevin Schwartzman Simon Rousseau Article 1: Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium May 12, 2023 No Journal Club June 2, 2023 Marta Kaminska Article 1: OSA Was Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
2022-2023 RECRU Seminars
DATE PRESENTER September 9, 2022 Benjamin Smith October 14, 2022 Bryan Ross December 2, 2022 Tania Janaudis-Ferreira December 9, 2022 Kevin Schwartzman January 27, 2023 Marc Parsons February 3, 2023 Jean Bourbeau April 14, 2023 Amanda Scanga, Teresa Gomes, Malhar Shah (Kaminska) May 5, 2023 Deborah Assayag May 12, 2023 Suurya Krishnan May 26, 2023 2:00 PM Nicole Ezer June 9, 2023 Sushmita Pamidi
2021-2022 RESP Journal Club
2021-2022 RECRU Seminars
DATE PRESENTER September 3, 2021 Deborah Assayag October 8, 2021 Benjamin Smith October 15, 2021 RECRU Meeting November 5, 2021 Khan (Chen) December 3, 2021 Marta Kaminska (Gomes) December 10, 2021 RECRU/TM Seminar: Brian Allwood February 4, 2022 Benjamin Smith February 11, 2022 Sushmita Pamidi March 11, 2022 Bryan Ross April 22, 2022 John Kimoff June 9, 2022 Sushmita Pamidi
2020-2021 Journal Club
DATE RECRU MODERATOR MEAKINS MODERATOR TOPIC & ARTICLE November 20, 2020 John Kimoff Carolyn Baglole Article 1: Factors associated with COVID-19-related death using OpenSAFELY Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV2 Receptor ACE2 in the Respiratory Tract December 11, 2020 Sana Swaleh Dao Nguyen Article 1: Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial Pseudomonas aeruginosa Strain-sharing in Early Infection Among Children WithCystic Fibrosis January 29, 2021 Faiz Ahmad Khan Article 1: Chest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease February 12, 2021 Kevin Schwartzman Maziar Divangahi Article 1: Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination March 19, 2021 Deborah Assayag Gregory Fonseca Article 1: Telomere Length and Genetic Variant Associations with Interstitial Lung Disease Progression and Survival Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis April 16, 2021 Marta Kaminska Article 1: The Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality May 14, 2021 Nicole Eze rJames Martin Article 1: Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells June 11, 2021 Bryan Ross Dennis Jensen Article 1: Submaximal Eccentric Cycling in People With COPD Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses Are the “critical” inspiratory constraints actually decisive to limit exercise tolerance in COPD?
2020-2021 RECRU Seminars
DATE PRESENTER June 4, 2021 Bryan Ross June 18, 2021 Marta Kaminska