RESP Journal Club

2022-2023 RESP Journal Club
Welcome to the joint RESP JOURNAL CLUB with RECRU and Meakins members. This journal club is open to all clinical and research faculty, trainees, fellows, and residents. The goal of this journal club is to critically evaluate a research article (or topic) from both clinical and fundamental science perspectives. Publications will be jointly chosen by RECRU and Meakins faculty members, who will facilitate discussion of the article. The publications will cover the various research themes of the RESP program, with a focus on translational research. Presentations will be delivered by faculty and/or trainees/fellows and all discussions will be moderated. Articles will be distributed 1 week in advance of the Journal Club date.
Frequency: Monthly on Fridays at 12 noon via ZOOM

DATE	RECRU MODERATOR	MEAKINS MODERATOR	TOPIC & ARTICLE
October 21, 2022	Deborah Assayag	Jun Ding	Article 1:   The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality Article 2:  An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
November 18, 2022	Benjamin Smith	Jun Ding	Article1: Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation Article 2:  Exhaustion of airway basal progenitor cells in early and established chronic obstructive pulmonary disease
January 13, 2022	Faiz Ahmed Khan		POSTPONED
February 3, 2023	Sushmita Pamidi	Basil Petrof	Article 1: Inflammasome Activation: A Keystone of Proinflammatory Response in Obstructive Sleep Apnea Article 2: Positive Airway Pressure Adherence, Mortality and Cardiovascular Events in Patients with Sleep Apnea
March 10, 2023	Kevin Schwartzman	Simon Rousseau	Article 1: Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California Article 2: Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
May 12, 2023	No Journal Club
June 2, 2023	Marta Kaminska		Article 1: OSA Was Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

Checklist and questions for presenters to integrate into their presentation and to use for moderating the discussion:

ACTS	INTERPRETATIONS
What is the stated rationale/motivation for this study?	Is this an important clinical/scientific problem?
What is the stated hypothesis (or objective)?	Does the hypothesis (or objective) address the stated rationale)?
What are the stated methods used to test the hypothesis (achieve the objective)?	Will the methods test the stated hypothesis?
What are the results?	Are the results presented appropriately?
What is the authors’ interpretation of the results?	Do you agree with their interpretation? Are they making inferences that go beyond what the data show? (If a clinical study) Do the findings apply to our patient population? (If an interventional clinical study) Is the effect size clinically meaningful?
What are the stated limitations of the study?	Do you agree with the stated limitations? Are there other limitations?
	Does this study provide the definitive answer the original problem? Are other studies needed?

RECRU Seminars

RECRU seminars: Fridays at 1pm

DATE	PRESENTER

2021-2022 RESP Journal Club

DATE	RECRU MODERATOR	MEAKINS MODERATOR	TOPIC & ARTICLE
October 22, 2021	John Kimoff	Sabah Hussain	Article 1: Reboxetine plus Oxybutynin for Obstructed Sleep Apnea Treatment A 1-week Randomized, Placebo-controlled, Double-Blind Crossover Trial Article 2: Endogenous Excitatory Drive Modulating Respiratory Muscle Activity across Sleep–Wake States
November 26, 2021	Deborah Assayag	Gregory Fonseca	Article 1: Family History of Pulmonary Fibrosis Predicts Worse Survival in Patients With Interstitial Lung Disease Article 2: IL‐17A contributes to HSV1 infection‐induced acute lung injury in a mouse model of pulmonary fibrosis
February 18, 2022	Sushmita Pamidi	Basil Petrof	Article 1: Association Between Arousals During Sleep and Hypertension Among Patients With Obstructive Sleep Apnea Article 2: Daily Exposure to Mild Intermittent Hypoxia Reduces Blood Pressure in Male OSA Patients with Hypertension
March 18, 2022	Marta Kaminska		Article 1: Effects of Obstructive Sleep Apnea and Obesity on 30-Day Readmissions in Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Mediation Analysis
April 8, 2022	Benjamin Smith	Simon Rousseau	Article 1: Association between very to moderate preterm birth, lung function deficits and COPD at age 53 years. Lancet Resp Med Feb 2022 Article 2: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature March 2022
May 6, 2022	Kevin Schwartzman		Article 1: Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis

2020-2021 Journal Club

DATE	RECRU MODERATOR	MEAKINS MODERATOR	TOPIC & ARTICLE
November 20, 2020	John Kimoff	Carolyn Baglole	Article 1: Factors associated with COVID-19-related death using OpenSAFELY Article 2: Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV2 Receptor ACE2 in the Respiratory Tract
December 11, 2020	Sana Swaleh	Dao Nguyen	Article 1: Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial Article 2: Pseudomonas aeruginosa Strain-sharing in Early Infection Among Children WithCystic Fibrosis
January 29, 2021	Faiz Ahmad Khan		Article 1: Chest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease
February 12, 2021	Kevin Schwartzman	Maziar Divangahi	Article 1: Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis Article 2: Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
March 19, 2021	Deborah Assayag	Gregory Fonseca	Article 1: Telomere Length and Genetic Variant Associations with Interstitial Lung Disease Progression and Survival Article 2: Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
April 16, 2021	Marta Kaminska		Article 1: The Sleep Apnea-specific Pulse Rate Response Predicts Cardiovascular Morbidity and Mortality
May 14, 2021	Nicole Ezer	James Martin	Article 1: Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial Article 2: The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells
June 11, 2021	Bryan Ross	Dennis Jensen	Article 1: Submaximal Eccentric Cycling in People With COPD Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses Article 2: Are the “critical” inspiratory constraints actually decisive to limit exercise tolerance in COPD?