Position
Distinguished James McGill Professor, Department of Medicine, McGill University
Research Interests
I am currently involved in three main areas of research. First, we currently investigating molecular signaling pathways and mechanisms of action of angiogenesis factors in general and angiopoietins and Tie-2 receptors in particular. Current project include identification of transcription factor networks downstream from Tie-2 receptors both in endothelial cells and in cultured skeletal muscle satellite cells. In addition, we are exploring the biological functions of both angiopoietin-1 and angiopoietin-2 in regulating cytokine cascade and tissue injury in various models of inflammation including severe sepsis and acute lung injury. To achieve our objective in this area of research we have developed transgenic animal models to over-express angiopoietins selectively in the vasculature.
My second area of research is the biological roles of angiopoietins in skeletal muscle regeneration with particular emphasis on ventilatory muscle function. In this regard, we are investigating the effectiveness of gene therapy in which angiopoietins are delivered in vivo in various models of skeletal muscle injury and regeneration including cardiotoxin necrosis model and mdx model of Duchenne Muscular Dystrophy.
My third area of research interest is molecular mechanisms involved in skeletal muscle atrophy in general and regulation of autophagy and proteosomal pathways in particular. Current research projects include assessing the contribution of autophagic pathway to skeletal muscle protein degradation in human diaphragm during mechanical ventilation.
Sabah Hussain in the News

NSERC 2024 Research Grants Competition
Congratulations to Drs. Sabah Hussain and Anne-Marie Lauzon – recipients of the 2024 NSERC Discovery Grant

Spring 2023 Student Awards
Congratulations to the 2023 recipients of FRQS and CIHR studentship and fellowship awards! We wish you much success!

Spring 2022 Student Awards
Congratulations to the recipients of FRQS and CIHR studentship and fellowship awards! We wish you much success!
Contact Information
Meakins-Christie Laboratories
RI-MUHC, Block E
Office EM2.2224
Lab E03.4358
1001 Decarie Blvd.
Montreal QC H4A 3J1
Canada
Tel: 514-934-1934 Ext. 36016 (lab)
Tel: 514-934-1934 Ext. 34645 (office)
Tel: 514-934-1934 Ext. 76172 (admin)
Fax: 514-933-3962
E-Mail: sabah.hussain [at] muhc.mcgill.ca
Education & Training
MD U Baghdad, 1978
PhD (Physiol) McGill, 1989