Work by Drs. James Martin and Maziar Divangahi has uncovered a surprising natural defense mechanism that activates during pregnancy to protect against severe flu infections. Published in Science Advances, the study reveals that pregnancy triggers a powerful immune response in the nasal cavity, blocking the Influenza A virus from spreading to the lungs, where it can cause life-threatening complications.
Contrary to the belief that pregnancy increases susceptibility to infections, the team found that it strengthens antiviral defenses in mice. This response, driven by a specific immune cell, produces a molecule that fortifies protection in the nose and upper airways, acting as the body’s first line of defense.
The discovery could pave the way for new flu vaccines, especially for pregnant individuals who are at higher risk of severe illness. It may also benefit the general population, as researchers believe this immune response could be replicated outside of pregnancy, potentially leading to innovative nasal treatments or vaccines.
The findings open doors for developing strategies that prevent lung damage during flu or other viral infections like COVID-19, focusing on balancing the immune system rather than directly targeting the virus. This groundbreaking research offers hope for better flu protection for expectant mothers and beyond.
Read More
Scientists discover a natural flu defense mechanism that activates in the nasal cavity during pregnancy. Medicalxpress.com. McGill University. by Keila DePape. December 2, 2024.
Pregnancy enhances natural immunity to block severe flu. Scientists discover a natural flu defense mechanism that activates in the nasal cavity during pregnancy. The Institute News. December 12, 2024.
Read the Article:
Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17-producing γδ+ T cells in the nasal mucosa. Chronopoulos J, Pernet E, Tran KA, McGovern TK, Morozan A, Wang S, Tsai O, Makita K, Divangahi M, Martin JG. Sci Adv. 2024 Sep 27;10(39):eado7087.
CTV Newscast
Pregnancy enhances natural immunity to block severe flu (newsclip at 17:28 minute mark) Maya Johnson, CTV News at 5, CTV Montreal, December 3, 2024.
Pregnancy enhances natural immunity to block severe flu (newsclip at 1:48 minute mark) Global News Hour at 6 Edmonton, December 23, 2024.