What a way to start 2023! Congratulations to Drs. Erwan Pernet and Maziar Divangahi and all the collaborators on the Nature publication. In this study, they show that the production of eicosanoids by neutrophils is required for reprogramming alveolar macrophages during early life in the developing lung. Furthermore, they demonstrate that in the absence of alveolar macrophage reprogramming by neutrophils, there is an increased susceptibility to LPS-induced acute lung injury, pulmonary influenza A virus and SARS-CoV-2 infections in preclinical models. These results highlight the complexity of prenatal macrophage programming and its subsequent impact on immunity to pulmonary sterilized inflammation as well as infectious diseases.
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M. Nature. 2023 Jan 4. doi: 10.1038/s41586-022-05660-7. PMID: 36599368
Alveolar macrophages, the lungs’ safeguard. by K. Coco Zhang. The McGill Tribune. March 7, 2023.